Description
Buy Beta-Amyloid (1-40), Y10W Mutant for Laboratory Research with Discreet Worldwide Shipping
Beta-Amyloid (1-40), Y10W Mutant is a synthetic research peptide based on the 40-amino-acid beta-amyloid (Aβ1-40) sequence. The Y10W designation identifies a specific amino-acid substitution in which tyrosine at position 10 is replaced by tryptophan.
Aβ1-40 is one of the major beta-amyloid peptide species investigated in biochemical, biophysical and neuroscience research. Researchers use synthetic Aβ peptides to investigate peptide aggregation, molecular interactions, fibril formation, membrane interactions and other aspects of amyloid biology.
The Y10W modification is particularly relevant to experimental studies in which researchers need to distinguish or monitor the modified peptide using analytical or spectroscopic approaches. The introduction of tryptophan can provide an intrinsic fluorescence signal that can be useful in experimental peptide studies.
ChemDirect should position this material as a laboratory research reagent, with the exact sequence, molecular characteristics, purity and analytical results verified against the applicable batch documentation.
What Is Beta-Amyloid (1-40), Y10W Mutant?
Beta-amyloid 1-40, commonly abbreviated Aβ1-40, is a 40-amino-acid peptide derived from the amyloid precursor protein (APP). It is one of the extensively studied forms of amyloid-beta in molecular and neuroscience research.
The Y10W mutant contains a targeted substitution at residue 10:
Tyrosine (Y) → Tryptophan (W)
This modification changes one amino acid while retaining the overall 40-residue peptide framework.
Basic Product Profile
| Property | Standard Information |
|---|---|
| Product Name | Beta-Amyloid (1-40), Y10W Mutant |
| Alternative Name | Aβ1-40 Y10W |
| Peptide Length | 40 amino acids |
| Mutation | Y10W |
| Position Modified | Residue 10 |
| Original Residue | Tyrosine (Y) |
| Substituted Residue | Tryptophan (W) |
| Product Category | Research peptide |
| Intended Use | Laboratory research |
| Physical Form | Typically lyophilized peptide |
| Purity | Batch-specific COA |
| Identity Testing | LC-MS or equivalent, where performed |
| Purity Testing | HPLC or equivalent, where performed |
How Does Beta-Amyloid (1-40), Y10W Mutant Work in Biological Research?
Aβ1-40 is studied primarily for its biochemical and biophysical behavior, particularly its ability to undergo conformational changes and form different aggregated structures under experimental conditions.
The Y10W substitution provides researchers with a modified Aβ sequence that can be compared with the corresponding wild-type peptide.
Amyloid Aggregation Research
Researchers investigate how Aβ peptides transition between monomeric, oligomeric and fibrillar states.
Fluorescence-Based Research
Because tryptophan has intrinsic fluorescence properties, replacing tyrosine with tryptophan can provide an experimentally useful optical probe.
Peptide Structure Studies
The mutant can be used to examine how a single amino-acid substitution affects peptide conformation and intermolecular interactions.
Molecular Interaction Studies
Aβ1-40 variants can be used in experimental investigations of interactions with proteins, membranes, small molecules and other biological materials.
Key Research Characteristics of Beta-Amyloid (1-40), Y10W
40-Residue Amyloid Peptide
The product is based on the Aβ1-40 peptide containing 40 amino acids.
Defined Y10W Substitution
The mutation replaces the tyrosine at position 10 with tryptophan.
Fluorescence Research Potential
The introduced tryptophan residue can provide an intrinsic fluorescence signal useful in certain experimental approaches.
Amyloid Biology Research
The peptide is relevant to research investigating amyloid structure, aggregation and molecular interactions.
Comparative Research
Researchers can compare the Y10W mutant with wild-type Aβ1-40 or other Aβ variants.
Product Details and Purity
Beta-Amyloid (1-40), Y10W Mutant is a synthetic peptide designed for laboratory research.
The defining structural feature is the Y10W substitution, where tyrosine at position 10 is replaced by tryptophan.
For ChemDirect, the exact sequence, molecular formula, molecular weight, salt form and purity should be taken from the manufacturer’s certificate of analysis because peptide preparations may differ according to their chemical form and counterions.
Recommended Product Information
- Peptide: Beta-Amyloid 1-40 Y10W
- Length: 40 amino acids
- Mutation: Y10W
- Mutation location: Position 10
- Original amino acid: Tyrosine
- Substituted amino acid: Tryptophan
- Product type: Synthetic research peptide
- Purity: Batch-specific
- Physical form: Typically lyophilized powder
Beta-Amyloid (1-40), Y10W Mutant Specifications
| Specification | Details |
|---|---|
| Product | Beta-Amyloid (1-40), Y10W Mutant |
| Common Abbreviation | Aβ1-40 Y10W |
| Peptide Length | 40 amino acids |
| Mutation | Y10W |
| Mutation Position | 10 |
| Native Residue | Tyrosine |
| Mutant Residue | Tryptophan |
| Product Type | Synthetic research peptide |
| Physical Form | Typically lyophilized powder |
| Appearance | Typically white to off-white |
| Purity | See batch-specific COA |
| Identity | LC-MS where applicable |
| Purity Analysis | HPLC where applicable |
| Intended Use | Laboratory research only |
| Documentation | COA/SDS where available |
Potential Applications — For Research Use Only
Beta-Amyloid (1-40), Y10W Mutant can be relevant to several areas of experimental research.
Amyloid Aggregation Studies
Research can examine the formation and behavior of Aβ aggregates under controlled experimental conditions.
Fluorescence Spectroscopy
The introduced tryptophan residue can be useful in fluorescence-based investigations of peptide structure and molecular interactions.
Protein-Protein Interaction Research
The peptide can be investigated in experimental systems examining interactions between Aβ and other proteins.
Membrane Interaction Studies
Researchers can investigate how Aβ peptides interact with lipid membranes and model membrane systems.
Structural Biology
The mutant can be used as an experimental variant for studying peptide conformation and structural properties.
Alzheimer’s Disease Research
Aβ peptides are widely used as research tools in studies investigating the molecular biology of amyloid-related processes. This does not mean that the product is a treatment for Alzheimer’s disease.
Research Handling and Storage
Aβ peptides can be sensitive research materials, and appropriate handling is important for maintaining experimental consistency.
- Lyophilized Powder: Keep at -20°C (or colder) for up to 12 months before reconstitution. Protect from light and moisture.
General laboratory practices include:
- Maintain the product in its original container.
- Follow the supplier’s storage specifications.
- Minimize unnecessary environmental exposure.
- Avoid contamination.
- Maintain accurate batch identification.
- Consult the product’s COA and SDS.
- Follow institutional laboratory procedures.
Because aggregation behavior is an important aspect of amyloid research, researchers should follow their validated experimental protocols when preparing and handling Aβ peptides.
Dosage & Usage Guidelines
Because this is a research reagent rather than an approved medicine, ChemDirect do not provide human dosing or self-administration instructions.
Safety, Side Effects & Precautions
This product should be handled as a laboratory research material.
Researchers should:
- Review the applicable SDS before handling.
- Use appropriate laboratory PPE.
- Avoid unnecessary exposure.
- Prevent contamination.
- Follow institutional laboratory safety procedures.
- Store the product according to manufacturer instructions.
- Dispose of research materials according to applicable laboratory requirements.
For laboratory research purposes only. Not intended for human consumption, self-administration, diagnosis, treatment or prevention of disease.
Quality Assurance & Testing
ChemDirect emphasize on analytical transparency for specialized peptide variants such as Aβ1-40 Y10W.
Peptide Identity
Identity can be verified using appropriate analytical techniques such as mass spectrometry where performed.
Purity Analysis
HPLC or an equivalent validated analytical method may be used to assess peptide purity.
Mutation Verification
For a specialized mutant peptide, analytical characterization should confirm the intended sequence or molecular identity.
Commitment to Quality and Compliance
ChemDirect provide:
- Accurate peptide identification
- Defined mutation information
- Batch traceability
- Transparent specifications
- Appropriate analytical testing
- COA/SDS documentation where available
- Responsible sourcing
- Research-only labeling
- Secure product packaging
Why Choose ChemDirect for Beta-Amyloid (1-40), Y10W Mutant?
Specialized Research Material
The Y10W mutation provides researchers with a defined Aβ1-40 variant for specialized experimental applications.
Clearly Defined Modification
The product specifically identifies the substitution at position 10.
Research-Focused Product
The material is positioned for laboratory and scientific research.
Analytical Documentation
Where available, COA and analytical information can help researchers evaluate product quality.
Batch Transparency
Batch-specific documentation provides greater confidence in peptide identity and purity.
Customer Support
ChemDirect can assist researchers with general product and documentation questions.
Shipping & Delivery Information
Order Processing
Orders are processed according to ChemDirect’s current fulfillment schedule.
Packaging
Research peptides should be packaged appropriately to protect product integrity during transportation.
Discreet Packaging
Where available, discreet external packaging may be used.
International Shipping
International availability depends on destination regulations and applicable import restrictions.
Customers should verify local requirements before ordering specialized research materials.
Tracking
Tracking information can be provided where supported by the shipping method.
How to Order Online
Step 1: Review the Beta-Amyloid Y10W product specifications.
Step 2: Confirm that the product is the Aβ1-40 Y10W mutant rather than wild-type Aβ1-40.
Step 3: Select the required quantity.
Step 4: Add the product to your cart.
Step 5: Complete checkout.
Step 6: Review and confirm your order.
Step 7: Use available tracking information to monitor shipment progress.
Frequently Asked Questions
What is Beta-Amyloid (1-40)?
Beta-Amyloid 1-40, or Aβ1-40, is a 40-amino-acid peptide extensively studied in amyloid and neuroscience research.
What does Y10W mean?
Y10W means that the tyrosine (Y) residue at position 10 has been replaced by tryptophan (W).
How long is Aβ1-40 Y10W?
The peptide contains 40 amino acids.
Why is tryptophan introduced at position 10?
Tryptophan has intrinsic fluorescence properties, making the Y10W substitution useful in certain experimental studies involving peptide structure, interactions and conformational behavior.
Is Y10W the same as wild-type Aβ1-40?
No. Wild-type Aβ1-40 contains tyrosine at position 10, whereas the Y10W variant contains tryptophan at that position.
What is Aβ1-40 studied for?
Aβ1-40 is studied in areas including amyloid aggregation, structural biology, molecular interactions, membrane interactions and neuroscience research.
Is this product a treatment for Alzheimer’s disease?
No. It is a laboratory research material and should not be marketed as an Alzheimer’s disease treatment.
What purity does ChemDirect’s Y10W peptide have?
97% purity
What form does the peptide come in?
Synthetic research versions are commonly supplied as a lyophilized peptide, but ChemDirect should describe the actual physical form supplied for the relevant batch.
How should the peptide be stored?
Follow the manufacturer’s storage instructions for the specific product and batch.
Related Products to Beta-Amyloid (1-40), Y10W Mutant
- Beta-Amyloid (1-40)
- Beta-Amyloid (1-42)
- Other beta-amyloid research peptides
- Other modified peptide variants
- Research-grade synthetic peptides
- Related laboratory research materials
Final Thoughts
Beta-Amyloid (1-40), Y10W Mutant is a specialized synthetic research peptide based on the 40-amino-acid Aβ1-40 sequence. Its defining modification is the replacement of tyrosine at position 10 with tryptophan, creating a useful experimental variant for biochemical, structural and fluorescence-based research.
The product can be particularly relevant to researchers studying amyloid aggregation, peptide conformation, molecular interactions, membrane interactions and amyloid-related neuroscience. The Y10W modification can also provide an intrinsic fluorescent probe for selected experimental designs.
For ChemDirect, the product page should emphasize precise sequence identification, mutation information, batch-specific purity, analytical testing, appropriate storage and transparent research-use labeling rather than making claims about treating or preventing human disease.Beta-Amyloid (1-40) Y10W Mutant
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